EDGE aims at communicating the diseases caused by herpesvirus, new approaches to treat such diseases, and cutting-edge research of EDGE on virus-host interactions and therapy to a broader audience. EDGE wants to broadly stimulate the public interest in research and innovation to inspire the next generation of researchers, developers and entrepreneurs. Information and teaching of the public involves participation in research nights, teaching and project programs, e.g. at local high schools. We further seek to disseminate our results to newspapers and other lay media after major goals have been achieved The aim of these communication activities is to bring updated knowledge on viruses and immunology to people working in closely related non-academic sectors, and also to inspire especially young people for a career in science and innovation.

International press release (in English) http://www.eurekalert.org/pub_releases/2016-04/au-jer041916.php

Local press release at Aarhus University, Denmark (in English) http://newsroom.au.dk/en/news/show/artikel/faelles-europaeisk-forskning-mod-herpesvirus/ 



Publications in peer-reviewed journals:




1) Biological relevance of Cytomegalovirus genetic variability in congenitally and postnatally infected children.

Galitska G, Biolatti M, De Andrea M, Leone A, Coscia A, Bertolotti L, Ala U, Bertino E, Dell'Oste V, Landolfo S.

J Clinic Virol. 2018 Oct 2. https://doi.org/10.1016/j.jcv.2018.09.019 


2) Evasion Strategy of Human Cytomegalovirus to Escape Interferon-β-Induced APOBEC3G Editing Activity.

Pautasso S, Galitska G, Dell'Oste V, Biolatti M, Cagliani R, Forni D, De Andrea M, Gariglio M, Sironi M, Landolfo S.

J Virol. 2018 Jul 25. pii: JVI.01224-18. doi: 10.1128/JVI.01224-18. [Epub ahead of print]

PMID: 30045985


3) The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins.

Praest P, Luteijn RD, Brak-Boer IGJ, Lanfermeijer J, Hoelen H, Ijgosse L, Costa AI, Gorham RD Jr, Lebbink RJ, Wiertz EJHJ.

Mol Immunol. 2018 Jun 4;101:55-64. doi: 10.1016/j.molimm.2018.05.025. [Epub ahead of print]

PMID: 29879547


4) Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.

Carter-Timofte ME, Hansen AF, Christiansen M, Paludan SR, Mogensen TH.

Genes Immun. 2018 May 1. doi: 10.1038/s41435-018-0027-y. [Epub ahead of print]

PMID: 29728610



5) New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins.

Praest P, Liaci AM, Förster F, Wiertz EJHJ.

Mol Immunol. 2018 Mar 29. pii: S0161-5890(18)30099-3. doi: 10.1016/j.molimm.2018.03.020. [Epub ahead of print]

PMID: 29606337


6) Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.

Döhner K, Ramos-Nascimento A, Bialy D, Anderson F, Hickford-Martinez A, Rother F, Koithan T, Rudolph K, Buch A, Prank U, Binz A, Hügel S, Lebbink RJ, Hoeben RC, Hartmann E, Bader M, Bauerfeind R, Sodeik B.

PLoS Pathog. 2018 Jan 5;14(1):e1006823. doi: 10.1371/journal.ppat.1006823. eCollection 2018 Jan.

PMID: 29304174


7) CRISPR approaching the clinic: When will this be a reality?

De Buhr H

Blog for Desktop Genetics LtD. 2018





8) KIF13A mediates trafficking of influenza A virus ribonucleoproteins.

Ramos-Nascimento A, Kellen B, Ferreira F, Alenquer M, Vale-Costa S, Raposo G, Delevoye C, Amorim MJ.

J Cell Sci. 2017 Dec 1;130(23):4038-4050. doi: 10.1242/jcs.210807. Epub 2017 Oct 23.

PMID: 29061883


9) Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression.

Eriksson K, Svensson A, Hait AS, Schlüter K, Tunbäck P, Nordström I, Padyukov L, Liljeqvist JÅ, Mogensen THPaludan SR.

J Immunol. 2017 Sep 11. pii: ji1700385. doi: 10.4049/jimmunol.1700385. [Epub ahead of print]

PMID: 2889395


10) Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.

Ogunjimi B, Zhang SY, Sørensen KB, Skipper KA, Carter-Timofte M, Kerner G, Luecke S, Prabakaran T, Cai Y, Meester J, Bartholomeus E, Bolar NA, Vandeweyer G, Claes C, Sillis Y, Lorenzo L, Fiorenza RA, Boucherit S, Dielman C, Heynderickx S, Elias G, Kurotova A, Auwera AV, Verstraete L, Lagae L, Verhelst H, Jansen A, Ramet J, Suls A, Smits E, Ceulemans B, Van Laer L, Plat Wilson G, Kreth J, Picard C, Von Bernuth H, Fluss J, Chabrier S, Abel L, Mortier G, Fribourg S, Mikkelsen JG, Casanova JL, Paludan SR, Mogensen TH.

J Clin Invest. 2017 Sep 1;127(9):3543-3556. doi: 10.1172/JCI92280. Epub 2017 Aug 7.

PMID: 2878304


11) PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production.

Serrero M, Planès R, Bahraoui E.

Sci Rep. 2017 May 24;7(1):2384. doi: 10.1038/s41598-017-02468-8.

PMID: 2853965