ESR1 - Proteome of cytosolic HSV-1 capsid interactions

Medizinische Hochschule Hannover, Germany; Supervisor: Beate Sodeik

Objectives

  • To describe the role of the innate cytosolic sensing systems in host defense against herpesvirus capsids.
  • To identify cell-type specific cytosolic host factors interacting with HSV-1 or VZV capsids.
  • To identify structural HSV1 proteins interacting with these cytosolic host factors.
  • To characterize the role of these factors in restricting lytic HSV-1 or VZV infection.

Expected achievements

  • Set-up in vitro systems to identify host factors specifically interacting wit HSV1 capsids.
  • This project will identify cell-type specific host proteins of epithelial, neuronal and immune cells. that specifically interact with incoming capsids and contribute to restricting or enabling HSV-1 and VZV infection.

Planned Secondments

  • Max Planck Institute, Munich, Germany; Affinity purification followed by mass spectrometry.
  • University of Oxford, UK; Modulation of VZV infections by RNAi against specific host factors.

Requirements

  • Excellent background in biochemistry, expertise in cell biology and/or virology would be an asset
  • Experience with mass spectrometry would be a strong asset
  • Ability to manage large experimental setups and large data sets

Appointment details

Based on a full-time appointment, the duration of the appointment as a Marie Curie ITN fellow will be for a maximum period of 3 years. The PhD student will become member of the Hannover Biomedical Research School in the Program of Infection Biology (ZIB) at Hannover Medical School, and is expected to present her/his work at the annually ZIB Symposium and to follow the mandatory training program.

 


 

Contact details

Beate Sodeik, Professor

Institute of Virology

Hannover Medical School

Hannover, Germany

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http://www.mh-hannover.de/ag-sodeik.html