Medizinische Hochschule Hannover, Germany; Supervisor: Beate Sodeik
- To describe the role of the innate cytosolic sensing systems in host defense against herpesvirus capsids.
- To identify cell-type specific cytosolic host factors interacting with HSV-1 or VZV capsids.
- To identify structural HSV1 proteins interacting with these cytosolic host factors.
- To characterize the role of these factors in restricting lytic HSV-1 or VZV infection.
- Set-up in vitro systems to identify host factors specifically interacting wit HSV1 capsids.
- This project will identify cell-type specific host proteins of epithelial, neuronal and immune cells. that specifically interact with incoming capsids and contribute to restricting or enabling HSV-1 and VZV infection.
- Max Planck Institute, Munich, Germany; Affinity purification followed by mass spectrometry.
- University of Oxford, UK; Modulation of VZV infections by RNAi against specific host factors.
- Excellent background in biochemistry, expertise in cell biology and/or virology would be an asset
- Experience with mass spectrometry would be a strong asset
- Ability to manage large experimental setups and large data sets
Based on a full-time appointment, the duration of the appointment as a Marie Curie ITN fellow will be for a maximum period of 3 years. The PhD student will become member of the Hannover Biomedical Research School in the Program of Infection Biology (ZIB) at Hannover Medical School, and is expected to present her/his work at the annually ZIB Symposium and to follow the mandatory training program.
Beate Sodeik, Professor
Institute of Virology
Hannover Medical School