ESR6 - Stimulation of innate immune responses by herpesvirus DNA

Aarhus University, Denmark; Supervisor: Søren Paludan

Objectives

  • To identify early events in cellular sensing of herpesvirus genomic DNA
  • To describe how signal transduction stimulated by herpesvirus DNA is initiated in infected cells

Expected achievements

  • Identification of molecular events that prime a cell for sensing of herpesvirus DNA
  • Full evaluation of the cross-talk between the herpesvirus entry pathway and release of viral DNA to DNA sensors
  • Characterization of an interaction between herpesviruses and cellular organelles of importance for activation of the cGAS-STING pathway

Planned Secondments

  • Helmholtz-Zentrum For Infection Research, Braunschweig, Germany; Evaluation of results in infections with cytomegalovirus
  • JENA Biosciences GmbH, Germany; CLICK-based methods for labelling of viruses and cells

Requirements

  • Solid theoretical background/expertise in cell biology and immunology
  • Experience with confocal microscopy and biochemistry
  • Ability to run a project involving a large number of methods

Appointment details

Based on a full-time appointment, the duration of the appointment as a Marie Curie ITN fellow will be for a maximum period of 3 years. The PhD student will become member of the Graduate School of The Faculty of Health Sciences, Aarhus University, and is expected to present her/his work at the annually PhD Day in the Graduate School and to follow the mandatory training program.

 


 

Contact details

Søren Riis Paludan, Professor

Department of Biomedicine

Aarhus University

Denmark

 

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http://www.paludanlab.dk

http://www.cii.au.dk