ESR7 - Immune responses induced by replication-incompetent HSV-2

Crucell-Janssen, Netherlands; Supervisor: Hanneke Schuitemaker

Objectives

  • To describe the innate immune response induced by a non-replicating herpes simplex vaccine
  • To identify how the innate immune responses modulate vaccine induced adaptive responses

Expected achievements

  • Set-up and use of in vitro systems to identify innate immune factors induced by the vaccine for later in vivo studies and in vitro characterization of the vaccine antigen expression
  • Extensive characterization of the innate immune response induction after vaccination with herpes simplex vaccine in vivo
  • Identification of the key innate immune response factors that modulate the adaptive immune response in vivo

Planned Secondments

  • Helmholtz-Zentrum For Infection Research, Braunschweig, Germany; Evaluation of herpes simplex vaccine in knock out mice
  • Aarhus University, Aarhus, Denmark; Evaluation of herpes simplex vaccine in knock out mice

Requirements

  • Solid background/expertise in cell biology, virology, and immunology
  • Experience with rodent models
  • Ability to manage large experimental setups

Appointment details

Based on a full-time appointment, the duration of the appointment as a Marie Curie ITN fellow will be for a maximum period of 3 years. The PhD student will become member of the Graduate School of Amsterdam Medical Center, University of Amsterdam and is expected to present her/his work at the annually PhD Day in the Graduate School and to follow the mandatory training program.

 


 

Contact details

Hanneke Schuitemaker and Roland Zahn

Janssen Biologics BV

Einsteinweg 101

2333 CB Leiden

The Netherlands

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